Hyperpolarization-activated currents (IH), mediated by HCN channels, play a critical role in regulating thalamic oscillations and neuronal excitability. We examined their functional expression in the ventrobasal nucleus (VB) of female mice and the modulatory effects of sex hormones and metabolic state. Whole-cell recordings were performed in VB neurons from wild-type (WT) and leptin-deficient (ob/ob) mice. Estrous cycle phases, ovariectomy, and mechanical sensitivity assessed with the Von Frey test were evaluated. IH shows sexual dimorphism: in WT females, IH increases with age (25-30 PND: n=8; 35-60 PND: n=12; P<0.05, T-test), while ovariectomy (OVX) prevents this enhancement (sham: n=7; OVX: n=11; P<0.05, T-test), highlighting a key role for sex hormones. In ob/ob females, whose estrous cycle is disrupted, IH remains stable and resembles the male pattern (n=11,12). Behavioral analyses revealed mechanical sensitivity is similar between WT (n=7) and ob/ob (n=6) females, whereas ob/ob males (n=8) show higher sensitivity than WT males (n=15) (MLM). WT females show no estrous cycle–dependent differences in mechanical sensitivity, while ob/ob females display increased sensitivity during diestrus vs estrus (n=7,5; P<0.05, T-test). These findings indicate HCN channel function in VB neurons is regulated by sex hormones and leptin, and that metabolic and hormonal imbalances differentially shape thalamic excitability and somatosensory processing in a sex- and cycle-dependent manner.