Sleep disturbances are increasingly recognized as a major health issue in industrialized societies, with profound social and economic costs. Up to 60% of cancer patients experience some form of sleep disorder, often linked to poorer quality of life and prognosis. Epidemiological evidence also suggests that inadequate sleep increases the risk of colorectal cancer, pointing to a connection between sleep regulation and intestinal physiology. Yet, the mechanisms linking gut dysfunction and sleep remain poorly understood. To study these interactions, we induced epithelial hyperplasia in the adult fly midgut and monitored sleep behavior. Mated females with intestinal hyperplasia exhibited a marked increase in daytime sleep, driven by longer sleep bouts, whereas males showed no significant changes, consistent with their weaker hyperplastic phenotype. Hidden Markov model analysis further revealed that this additional sleep corresponded to deep rather than light states, supporting the idea that intestinal hyperplasia produces both qualitative and quantitative changes in sleep regulation. Together, these results highlight the active role of intestinal epithelial integrity in shaping sleep dynamics. Future experiments will expand this work by testing how sleep disruption influences tumor growth and progression, and by dissecting the gut–brain signaling pathways that mediate this bidirectional relationship, with the ultimate goal of uncovering conserved mechanisms.