Garcinol is a naturally occurring compound that functions as a HAT inhibitor. In previous research, the administration of Garcinol has been observed to result in impaired memory reconsolidation in a rat model of addiction. Prior studies conducted within our lab show that histone acetylation constitutes a hallmark of long-lasting memories, yet its role is not indispensable for less persistent memories. In light of these findings, the present study was designed to ascertain the impact of systemic Garcinol administration on memory persistence in mice. We employed the novel object recognition task to determine the impact of the treatment both on long-term memory, measured 24 hours after training, and persistence, measured 7 days after training. After 7 days, garcinol showed an effect as mice explored equally both familiar and novel objects. Furthermore, when tested 24hs after training treatment did not affect long-term memory, as the two groups exhibited similar discrimination indices for both objects. However, animals that had been administered Garcinol exhibited a marked reduction in the amount of exploring time in comparison to the control group. Subsequent experiments using the Fear Conditioning task are currently being conducted to ascertain whether this impairing effect is contingent upon the task or memory type.