Peripheral nerve injuries are afflictions in which full recovery is rarely achieved with current treatments. Our group focuses on nanobiotechnological strategies to promote nerve regeneration though a Wallerian degeneration model in rats promoted by a 30 second sciatic nerve crush. In this work we present a systemically transplanted “hybrid platform” composed of poly-lactic-co-glycolic acid nanocapsules (NC), loaded with magnetic nanoparticles (MNP) and functionalized with polyethyleneimine (PEI) for the transfection and magneto targeting of bone marrow mononuclear cells (BMMC) to the injury site. Both PLGA-NC and MNP were thoroughly characterized by specific techniques. To evaluate the “hybrid platform” feasibility, initial studies the “hybrid platform” were performed using BMMC transfected with NC:PEI:DNA (mock plasmid) loaded with MNPs and labeled with a fluorochrome. Seven days post-treatment behavioral and immunofluorescence assays for myelin basic protein (MBP) detection were performed. The results obtained show that the “hybrid platform” not only does not hinder the analgesic effects of BMMC but also was optimized by magneto targeting. Lastly preliminary results employing the “hybrid platform” adsorb with mRNA of native BDNF show a promising outcome and encourage us to further explore this nanotechnological approach as a potential therapeutic strategy and a tool to better understand the mechanism involved in nerve regeneration.