Natural products have been investigated as potential sources of neuroprotective agents, with Cannabis sativa emerging as a particularly promising candidate. In this sense, the objective was to evaluate the effects of concomitant treatment with Cannabis sativa extract (CSE) in a reserpine-induced parkinsonism model on motor changes. Thus, 35 male Wistar rats were divided into 5 groups (n= 7): CTL, CSE 8.3, RES (0.5 mg/kg), RES-CSE 5.0, and RES-CSE 8.3. The experiment lasted 30 days. In this interval, behavioral tests were performed: catalepsy (every 48 h), oral movements (OM - days 8, 20, and 30), and body mass (BM) was measured every 4 days. All procedures were approved by CEUA, under protocol nº. 1509230425. As a result, it was observed that reserpine administration induced motor changes in all parameters analyzed, and treatment with the lowest dose of CSE (5.0 mg/kg) in catalepsy showed more evident benefits in attenuating motor impairment and muscle rigidity in the animals from the 6th day onwards, with a sustained effect until the end of the experiment. In the OM test, both doses of CSE demonstrated neuroprotective effects in the late phase (30th day) by reducing the number of tongue protrusions and vacuum chewing. Similarly, in the assessment of the ' BM, only in the final phase of the protocol was there a reduction in weight loss, coinciding with the behavioral findings. CSE attenuated motor alterations and reduced late weight loss, suggesting a neuroprotective effect.