Animals tend to avoid aversive or stressful experiences and select actions intended to escape from those situations. However, if the action (escape) fails to counteract the aversive event, animals may adaptively suppress the escape. Repeated failure to avoid an aversive stimulus by performing an escape can result in a deep discounting of the value of escaping. In humans, this discounting is maladaptive when manifesting as hopelessness, one of the core clinical criteria of major depressive disorder. Social isolation during early development can affect judgement of the value of negative events and is in addition a contributing factor to depression.
Our lab studies how social isolation affects behavioral decisions and particularly the judgement of negative events using zebrafish as model system. We aim to determine whether hopelessness can be affected by social isolation during early development. To do this we implemented a passive coping assay for larval zebrafish: 15 days old larvae raised either in a social context or in isolation were exposed to an inescapable aversive stimulus (mild shock) to study the transition from an active coping mechanism characterized by attempts to escape to a passive coping mechanism where mobility is reduced. Here we present our first preliminary results analyzing whether social- or isolated raised larvae show differences in reactivity to the aversive stimulus and in the transition from active to passive coping strategies.