V-046
Electrophisiological Dynamics in an Aversive Conditioning Paradigm in Humans
Ron Tzvi Itzigsohn1, Pedro Beckinschtein2
  1. ITBA
  2. INECO
  3. Universidad Favoloro
Presenting Author:
Ron Tzvi Itzigsohn
ritzigsohn@itba.edu.ar
Recognition of threats is crucial for survival, but it can also contribute to the development and persistence of pathological fear, as observed in anxiety disorders and post-traumatic stress disorder (PTSD). Aversive conditioning paradigms, particularly Pavlovian fear conditioning, have been instrumental in elucidating the mechanisms of fear acquisition, reconsolidation, and extinction. Evidence suggests that reactivation of fear memories can render them labile and susceptible to modification, offering potential therapeutic avenues for modulating maladaptive responses. In this study, we employed a novel aversive conditioning paradigm in which participants were exposed to air puffs as aversive stimuli, paired with specific geometric shapes. Subjects developed conditioned blink responses to these shapes. After 24 hours, extinction was assessed by presenting the shapes without the aversive stimulus, during which we observed short-lived sustained habituation and extinction. Our central hypothesis is that individuals with anxiety disorders will exhibit enhanced habituation compared to neurotypical controls, as well as be characterized by a faster rate of habituation, stronger conditioned responses, and prolonged extinction trajectories. By combining behavioral measures with established frameworks of fear learning and extinction, this work aims to advance our understanding of how anxiety affects the formation of aversive memories, utilizing non-invasive methods.