Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder worldwide, is characterized by motor impairments primarily linked to the degeneration of dopaminergic neurons in the Substantia Nigra pars compacta. Beyond motor dysfunction, non-motor symptoms such as sleep disturbances represent a significant but less explored dimension of the disease. Given the tight interplay between motor and sleep circuits, we propose that neurodegeneration in one system may precipitate dysfunctions in the other. Using Drosophila melanogaster as a model, we investigate the effects of PD-associated gene deregulation, including mutant α-synuclein, in neural centers regulating sleep and locomotion. We assess neuronal loss, locomotor performance, and sleep architecture in young and aged flies to uncover circuit-specific vulnerabilities and their contribution to disease progression.