*FP & AAVE have equal contribution. Pomacea canaliculate is the only freshwater snail listed as one of the 100 worst invasive species worldwide. Its eggs are protected by perivitelline fluid containing PcPV2, a protein with enterotoxic and neurotoxic activities. Although intraperitoneal (i.p.) PcPV2 causes neurological signs and even death in rodents, its behavioral effects remain unexplored. We evaluated adult male Sprague-Dawley rats (n=10/group) after i.p. PcPV2 (250 µg/kg) at two time points: early (days 3-6) and late (days 24-27). Behavioral parameters assessed included exploration and anxiety (open field test), recognition and spatial memory (novel object and location recognition test), species-typical behavior (marble burying), and sensorimotor performance (adhesive removal, inclined ramp). PcPV2-treated rats, at both time points, buried fewer marbles and exhibited impaired sensorimotor performance. In the open field, they showed increased immobility at both assessments, with reduced exploration only in the early phase. In cognitive tasks, they explored novel or displaced objects less than controls in the early window. Overall, PcPV2 induced significant behavioral and sensorimotor impairments, with some effects being transient and others persisting throughout the study, confirming its neurotoxic potential. This study provides the first comprehensive behavioral evaluation of ip PcPV2, offering a framework for future neurotoxicity research and mechanistic studies.