Neuropeptides are essential molecules in the regulation of physiological processes. They are produced by the central nervous system (CNS) and are recognized by specific receptors expressed in various cells of the CNS itself or in peripheral tissues. In this way, neuropeptide-mediated signaling controls processes such as sleep, stress response, emotions, among others. In Drosophila, some of these neuropeptides are produced by enteroendocrine cells (EECs), which are located in the intestinal epithelium. These cells are responsible for detecting changes in the conditions of the digestive tract and releasing neuropeptides in response to different stimuli. Although the involvement of neuropeptides in the aforementioned functions is known, their role in establishing gastrointestinal homeostasis has not been described in detail. In this study, we performed a screen of 16 neuropeptides expressed in Drosophila EECs, measuring feeding and defecation rates as parameters of gastrointestinal homeostasis. Preliminary results of this screen will be presented in the poster session