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Cognition, Behavior, and Memory

Posters List

S-052
Serotonin 2A receptor in the retrosplenial cortex play a key role in recognition memory
Beatriz Agustina Ortega1,2, Renato Salvatore2, Noelia V Weisstaub2,3, Cynthia Katche1,2
  1. Laboratorio de Memoria, Instituto de Biología Celular y Neurociencia “Prof. E. De Robertis” (IBCN), Facultad de Medicina, CONICET-UBA, Buenos Aires, Argentina.
  2. Instituto Tecnológico de Buenos Aires (ITBA), Buenos Aires, Argentina.
  3. Instituto de Neurociencia Cognitiva y Traslacional (INCYT). CONICET, Fundación INECO, Universidad Favaloro, Buenos Aires, Argentina.
Presenting Author:
Beatriz Agustina Ortega
ortegabeatrizagustina@gmail.com
The retrosplenial cortex (RSC) is particularly sensitive to changes that occur in mild cognitive impairment and Alzheimer's disease (AD), making understanding its function crucial. A main feature of the AD is its memory problems. In many cases, patients present psychosis. Dementia-related psychosis has no selective treatment, but recently the focus has been on serotoninergic drugs, particularly on a selective serotonin (5-HT) 2A inverse agonist, supporting a role for the serotoninergic system in AD treatment. 5-HT2A receptors (5-HT2AR) are highly expressed in cortical regions and have been linked to modulation of cognitive processes. However, its role in memory processes is not completely understood. Previously, we showed that RSC is involved in recognition memory. Since 5-HT2AR are expressed in RSC, we decided to investigate the role of 5-HT2AR in aRSC in different memory phases in the object recognition (OR). Using the Y-OR task combined with localized administration in the RSC of Ketenaserine, a selective 5-HT2 antagonist, we find that this receptor is required for memory formation. Furthermore, by infusing the selective 5-HT2A antagonist MDL into the RSC, we showed these receptors contribute differentially to acquisition, consolidation, and retrieval. These results suggest that 5-HT2AR in the RSC are required for OR memory processing and may be a promising therapeutic target.