Gestational stress alters the trajectory of brain development, leading to changes in cognitive and socioemotional functions. However, individual responses to stress vary, with some exhibiting resilience while others display heightened vulnerability. To investigate the mechanisms underlying stress resilience, we employed a gestational movement restriction model in which pregnant CF1 females were subjected to a restraint protocol from gestational day 10 to 19. Offspring were evaluated with the Splash Test, where latency to groom was used to distinguish between resilient (RES) and susceptible (SUS) mice. Behavioral responses were further assessed using the Forced Swim Test (FST). SUS mice exhibited significantly more passive and less active swimming compared to controls (CT), while no significant differences were observed between RES and CT. To explore potential molecular mechanisms of stress adaptation, RNA was extracted from the PFC of adult animals. Both RES and SUS groups showed significantly reduced expression of the Grin2b gene encoding an NMDAR subunit, and SUS mice exhibited a trend towards increased expression of the Gabrb3 gene encoding GABA-A subunit. A positive correlation was found between oxytocin receptor expression and the passive swimming time in the FST in RES animals. These findings enhance our understanding of the mechanisms underlying stress resilience and may guide future strategies to promote adaptive responses to adversity.