*FP & AAVE have equal contribution. Alzheimer’s disease (AD) is the leading cause of dementia and remains without effective therapeutic options. Women represent two-thirds of patients, yet female animals continue to be underrepresented in preclinical studies. The intracerebroventricular injection of streptozotocin (ICV-STZ) is a well-established model for inducing sporadic AD-like features, primarily developed and characterized in male rodents, whereas studies in females are relatively scarce. Building on this, the present study aimed to determine whether age further modulates the response to STZ in females. Sprague-Dawley rats aged 12 and 18 months were divided into four groups: 12mSham, 12mSTZ, 18mSham, and 18mSTZ. On experimental day (ED) 0, rats received bilateral ICV injections of either artificial cerebrospinal fluid (12mSham/18mSham) or 3 mg/kg of STZ (12mSTZ/18mSTZ). Among ED 14-25, a battery of behavioral tests was conducted to assess both general behavior and cognitive function. Our results show that STZ induces behavioral and cognitive impairments, with some effects being age-independent and others modulated by aging. Exploratory and anxiety-related behaviors were consistently affected by STZ, while freezing and spatial memory were influenced by age. Recognition memory was impaired by STZ in younger animals, whereas older rats already displayed age-related deficits. Our findings highlight the importance of considering both sex and age in preclinical models of AD.