In this cross-sectional study of 32 patients with idiopathic Parkinson’s disease (mean age 67 years, 56% male, mean disease duration 5 years), we evaluated the association between orthostatic hypotension (OH) and mood symptoms. All participants completed the MDS-UPDRS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and the Orthostatic Hypotension Questionnaire (OHQ), with orthostatic response measured by serial blood pressure and heart rate recordings. Mean BDI (10.0 ± 5.9) and BAI (8.8 ± 4.6) scores indicated mild depression and anxiety. No significant differences in depression or anxiety scores were observed between patients with or without OH (p = .86 in both cases). However, the severity of self-reported orthostatic symptoms correlated positively with anxiety levels (Pearson r = .49, p = .004; Spearman ρ = .53, p = .002), a finding that remained significant after adjusting for age, sex, and disease severity. Correlation with depression was positive but weaker and did not reach significance (Pearson r = .33, p = .061; Spearman ρ = .43, p = .014). These preliminary results suggest that while objective OH was not linked to mood disturbances, subjective orthostatic symptoms were associated with greater anxiety and, to a lesser extent, depression, underscoring the need to assess perceived autonomic symptoms in Parkinson’s care despite the study’s small sample size and measurement limitations.