Peripheral neuropathies are highly prevalent disorders whose clinical progression is often unfavorable due to the lack of effective therapies that comprehensively address patient needs. Previous studies of our lab have demonstrated the therapeutic potential of multipotent stem cells of bone marrow or adipose tissue origin; while there is some evidence that curcumin could aid regeneration due to its antioxidant and anti-inflammatory effects. In this context, the aim of the present study is to increase the bioavailability of curcumin to potentiate the regenerative effects of multipotent stem cells. PLGA nanocapsules were synthetized with different concentrations of curcumin solutions, to find a non-cytotoxic concentration for cells. For this, adult multipotent stem cells from bone marrow or adipose tissue, as well as Schwann cells, were used. Cell viability was assessed through MTT assay and fluorescence microscopy with vital dyes, as well as cell-type-specific markers. Encapsulation of 6 mg/ml curcumin in chloroform led to the formation of non-homogenous PLGA nanocapsules in terms of size, and cytotoxic for multipotent cells. 10 times curcumin concentration reduction led to more homogeneous nanocapsules but still cytotoxic for multipotent cells. Finding the correct concentration of curcumin may provide basis for new therapeutic strategies for treatment of peripheral neuropathies taking advantage of the anti-inflammatory and antioxidant effect of this natural compound.