Facebook X-twitter Linkedin

Posters

Disorders of the Nervous System

Posters List

D-083
Effect of fluoxetine on motor function and anxiety-like behavior in a reserpine-induced parkinsonism animal model
Mylaine Santos Mendonca1, Clarissa Gomes Andrade Alvaia2, Pollyana Caldeira Leal1, José Marcos Meneses Bispo1, João Eduardo Conceição Melo1, Edson de Rezende Santos1, Auderlan Mendonça de Gois1,3, Marco Aurélio de Moura Freire1, Katty Anne Amador Lucena de Medeiros1, Heitor Franco Santos1,2, Regina Helena da Silva 4, Alessandra Mussi Ribeiro5, Murilo Marchioro2, José Ronaldo dos Santos1
  1. Behavioral and Evolutionary Neurobiology Laboratory, Department of Bioscience, Federal University of Sergipe, Itabaiana, 49506-036, SE, Brazil
  2. Laboratory of Neurophysiology, Department of Physiology, Federal University of Sergipe, São Cristovão, 49100-000, SE, Brazil
  3. Neuromolecular Laboratory, Department of Bioscience, Federal University of Sergipe, Itabaiana, 49506-036, SE, Brazil
  4. Federal University of São Paulo and Name: Alessandra Mussi Ribeiro
  5. Federal university of São Paulo- Baixada Santist
Presenting Author:
Mylaine Santos Mendonça
mylaine99.ms@gmail.com
Parkinson’s disease (PD), the major motor disorder known, has been currently characterized also as a progressive multisystemic disease with non-motor symptoms (NMS) like depression, affecting around 50% of its sufferers. While selective serotonin reuptake inhibitors are the primary treatment for such NMS, studies on acutely induced parkinsonism have linked fluoxetine (FLU) to increased motor impairment. The present study aimed to assess fluoxetine’s effects in a parkinsonism model. Sixty-four male Wistar rats (7–9 months old) were divided into groups: 1) FLU + reserpine (RES) vehicle; 2) FLU 10 mg/kg + RES vehicle; 3) FLU 10 mg/kg + RES 0.1 mg/kg; 4) FLU vehicle + RES 0.1 mg/kg. Behavioral tests were made open field, catalepsy, and oral movements. Rats treated with both fluoxetine and reserpine displayed increased catalepsy duration, reduced travel, lower rearing, more tremulous jaw movements, and greater weight loss, with distinct immunohistochemical results between acute and prolonged treatments. Fluoxetine-treated rats showed reduced TH immunoreactivity in the dorsal striatum, decreased TH-positive cells in the SNpc, and increased serotonin in the dorsal raphe nucleus. Reserpine-treated rats showed reduced TH-positive cells in the SNpc and dorsal striatum, with no motor correlation. Our results pointed that fluoxetine exacerbated reserpine-induced motor alterations, which were not linked to TH immunohistochemical changes.