Sporadic Alzheimer’s disease (AD) is the most common form of dementia worldwide, with a genetic component accounting for 80%. To date, 83 SNPs across 75 loci have been identified in individuals of European ancestry. Some of these genetic signals were replicated in a population sample from Argentina (N=1028) and Chile (N=352) by Genome-wide Association Study (GWAS). These GWAS also revealed 15 novel variants with suggestive significance, not reported in Europeans or linked to AD before. With the aim to increase statistical power to validate these potential Latin American signals, we run a new GWAS using the GeNED.ar cohort (Genetics and Neuroimaging of Aging and Dementia in Argentina) with 300 additional samples (88 AD and 212 controls). Samples were genotyped in Germany using the Illumina GSA array. The quality control excluded samples and variants with missingness higher than 3%, excess of heterozygosity rate, sex discrepancies, duplicates, and relatedness (PI-HAT > 0.1875). After QC, 280 samples remained (80 AD and 200 controls). Data were imputed with minimac4 and the TOPMed reference panel via the Michigan Imputation Server. Ancestry analysis revealed an admixture between Indigenous American and European components. Principal components–adjusted logistic regression and meta-analysis with previous results will shed light to better understand the genetic architecture of AD in our admixed population.